HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,6-Hexanediol → Cholest-5-en-3beta-yl 6-hydroxyhexyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,6-Hexanediol | HCID 12374 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Cholest-5-en-3-yl 4-methylbenzenesulfonate | HCID 280698 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | Cholest-5-en-3beta-yl 6-hydroxyhexyl ether | HCID 13799769 | 52% |
Reaction Steps
By use of the procedure described in the literature [Kosower, E. M. and Weinstein, S., J. Am. Chem. Soc., 78 (1956) 4347-4354; and Davis, M., J. Chem. Soc., (1962) 178-181] cholesteryl p-toluenesulfonate and 1,6-hexanediol were condensed in boiling dioxane to give cholest-5-en-3β-yl 6-hydroxyhexyl ether in 52% yield as colorless plates (from hexane), m.p. 75.9°-81° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04652637 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-acd596d75854434dbf0daed186e1118d |
| Source note | uspto-grants-1987_03 |