Triethylamine → HCID 131715077, compound

Participants

Reaction Steps

38 mg (0.2 mmol) of (3S,4R)-3-amino-4-ethynyl-2-oxo-1-azetidinesulphonic acid, 77 mg (0.22 mmol) of 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino-acetic acid 2-benzthiazolyl thioester and 56 μl (0.4 mmol) of triethylamine are stirred at room temperature for 2 hours in 1 ml of acetone/water (4:1). The mixture is then filtered and evaporated. The residue is chromatographed over reverse-phase silica gel with water/methanol (2:1). After lyophilization, there are obtained 66 mg of amorphous (3S,4R)-3-[(Z)-2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-4-ethynyl-2-oxo-1-azetidinesulphonic acid triethylamine salt.

Provenance & Evidence