HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Fluoride → HCID 15058003, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | HCID 15058001 | HCID 15058001 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 15058003 | HCID 15058003 | 95.8% |
Reaction Steps
10.0 g (0.024 mol) of (3S,4S)-3-tritylamino-4-[2-(trimethylsilyl)ethynyl]-2-azetidinone and 1.5 g (0.026 mol) of potassium fluoride are stirred at 20° C. for 1.5 hours in 100 ml of ethanol and 100 ml of dimethyl sulphoxide. The solution is diluted with ether, the ether phase is washed with water, dried and evaporated. 8.1 g (85%) of crude (3S,4S)-4-ethynyl-3-tritylamino-2-azetidinone are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04652651 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-aec3ba8b0e52417dadc3ba68bc4dda67 |
| Source note | uspto-grants-1987_03 |