Trifluoroacetic acid → HCID 70373604, compound

Participants

Reaction Conditions

Reaction Steps

1.55 g (4.34 mmol) of (3R,4R)-3-(1-t-butoxyformamido)-4-[(E)-2-carbamoylvinyl]-2-oxo-1-azetidinesulphonic acid sodium salt are dissolved in 5 ml of anisole, the solution is cooled to 0° C. and then treated with 5 ml of trifluoroacetic acid. The suspension obtained is stirred at 0° C. for 1 hour and subsequently at room temperature for 2 hours. The mixture is diluted with 100 ml of ether and 20 ml of n-hexane. The crystals obtained are filtered off and dried. The thus-obtained crude material is dissolved in 10 ml of water and chromatographed on MCI gel using water for the elution. 1.04 g (100%) of (3S,4S)-3-amino-4-[(E)-2-carbamoylvinyl]-2-oxo-1-azetidinesulphonic acid are obtained.

Provenance & Evidence