Sodium Hydroxide → 2-chloro-N-(4,6-dimethoxy-5-pyrimidinyl)-N-(1-(1-pyrazolyl)ethyl)acetamide

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Reaction Steps

In a 500 ml eggplant-shaped flask equipped with a stirrer, 17.4 g (75.1 mmoles) of 2-chloro-N-(4,6-dimethoxy-5-pyrimidinyl)acetamide was dissolved in 300 ml of dichloromethane, and 5.22 g of benzyl tributyl ammonium chloride was added. Under ice cooling, 41.5 ml of a 50% aqueous solution of sodium hydroxide was added to the mixture with stirring. Thereafter, a solution of 13.8 g (82.6 mmoles) of N-(1-chloroethyl)pyrazole hydrochloride in 70 ml of dichloromethane was added dropwise over about 30 minutes. The mixture was stirred further at room temperature for 2 hours. The reaction mixture was washed with water, dried and concentrated. The resulting solid was recrystallized from isopropanol to give 9.26 g of 2-chloro-N-(4,6-dimethoxy-5-pyrimidinyl)-N-(1-(1-pyrazolyl)ethyl)acetamide as a pale yelllow solid which had the following properties.

Provenance & Evidence