Phosphorus oxychloride → HCID 178527218, compound

Participants

Reaction Steps

A solution of 13.84 g (0.049 mole) of 3-hydroxy-1,5-diphenyl-1H-1,2,4-thiadiazine-1-oxide of Example 7 in 50 ml of phosphorus oxychloride was refluxed for 30 minutes and then excess reagent was evaporated under vacuum. The residue was taken up in chloroform and the solution was washed once with water, dried over magnesium sulfate and evaporated to an oil. The residue crystallized on trituration with ethanol to obtain 10.8 g (73%) of 3-chloro-1,5-diphenyl-1H-1,2,4-thiadiazine-1-oxide melting at 117°-118° C.

Provenance & Evidence