Ethyl bromoacetate → HCID 178473167, compound

Participants

Reaction Conditions

Reaction Steps

1.22 g of 2-phenyl-3-hydroxy-7-mercapto-pyrazolo [4,3-d]pyrimidine was suspended in 100 ml of ethanol, and 0.5 g of potassium hydrogen carbonate was added. While heating the mixture at 80° C., 1 g of ethyl bromoacetate was dropwise added, and the heating and reaction were continued for further 2 hours. Then, the solvent was distilled off. Water was added to the residue, and the residue was dissolved. The solution was acidified with hydrochloric acid, and the precipitated crystals were extracted with chloroform. The chloroform layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off. The remaining solid was recrystallized from acetone-chloroform.

Provenance & Evidence