HCID 70351673, compound → HCID 70353565, compound

Participants

Reaction Steps

A solution of methyl 4-{[4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}but-2-ynoate (1.00 g) in dioxane (30 ml) was stirred under one atmosphere (1.0333 kg.cm.-2) of hydrogen at room temperature in the presence of 5% palladium on barium sulphate. When the uptake of hydrogen had ceased the mixture was filtered and evaporated. The residue was purified by chromatography on silica (6 g) using toluene plus 0→50% ethyl acetate as the eluant. Appropriate fractions were combined and evaporated and the residue crystallised from diisopropyl ether to give the title compound (0.40 g), m.p. 78°-80°.

Provenance & Evidence