Dichloromethane → N-[3-(3-Methyl-1,2,4-triazolo-[4,3-b]pyridazin-6-yl) phenyl]formamide

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Reaction Steps

To 5.53 ml of acetic-formic anhydride was added 250 ml dichloromethane followed by 10 g of 3-methyl-6-[3-(amino)-phenyl]-1,2,4-triazolo[4,3-b]pyridazine. The solution was stirred for 12 hours, then diluted with 1 liter of dichloromethane-methanol (9:1). This solution was washed with saturated aqueous sodium bicarbonate, dried, and concentrated in vacuo. The residue was recrystallized from dichloromethane-methanol to give 6.7 g of an off-white powder, mp 265°-268° C.

Provenance & Evidence