HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethyl-3-thiosemicarbazide → N-Methyl-N-[3-[3-(ethylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethyl-3-thiosemicarbazide | HCID 1551780 | — |
| Reactant | N-Methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide | HCID 15595702 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-Methyl-N-[3-[3-(ethylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide | HCID 15595690 | 16.9% |
Reaction Steps
A solution of 6.0 g N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide and 5.5 g 4-ethyl-3-thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours and treated in similar fashion to Example 67. Chromatography on silica gel and recrystalization from dichloromethane-hexane afforded 1.2 g yellow crystals, mp 225°-227° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04654343 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-dc21cfc99ec94e43b953d7499b3fd39d |
| Source note | uspto-grants-1987_03 |