N-Methylhydrazinecarbothioamide → HCID 15595691, compound

HRID 1906826Notes

Reaction equation

HRID 1906826 reaction equation
[CH2:1]([N:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]2[N:14]=[N:15][C:16](Cl)=[CH:17][CH:18]=2)[CH:8]=1)[C:4](=[O:6])[CH3:5])[CH3:2].[CH3:20][NH:21][C:22](=S)[NH:23][NH2:24]>C(O)C>[CH2:1]([N:3]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]3[N:15]([C:22]([NH:21][CH3:20])=[N:23][N:24]=3)[N:14]=2)[CH:8]=1)[C:4](=[O:6])[CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 2723853N-MethylhydrazinecarbothioamideHCID 14280297N-Ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide

Product 1

HCID 15595691HCID 15595691, compoundYield 26.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 7.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide and 5.3 g 4-methyl thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was worked up and the product chromatographed as described in Example 70. Recrystalization of the product fractions from dichloromethone-hexane afforded 2.1 g of yellow crystals, mp 193°-195° C.

Workup

  1. customthe product chromatographed
  2. customRecrystalization of the product fractions from dichloromethone-hexane

Sources & evidence

ORD record
ord-3811afbf84a04367bc05c39250fa6f09
Source dataset
uspto-grants-1987_03
Patent number
US04654343

Reaction notes

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