HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethyl-3-thiosemicarbazide → N-Ethyl-N[3-[3-(ethylamino)-1,2,4-triazolo-[4,3-b]pyridazin-6-yl]phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethyl-3-thiosemicarbazide | HCID 1551780 | — |
| Reactant | N-Ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide | HCID 14280297 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-Ethyl-N[3-[3-(ethylamino)-1,2,4-triazolo-[4,3-b]pyridazin-6-yl]phenyl]acetamide | HCID 15595692 | — |
Reaction Steps
A solution of 7.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide and 6.0 g 4-ethyl-3-thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was then worked up and the product chromatographed as described in Example 70. Recrystallization of the product from dichloromethane-hexane afforded 2.1 g yellow flakes, mp 171°-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04654343 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-630dfa27424f47b0bda856e167b44e40 |
| Source note | uspto-grants-1987_03 |