Sodium Hydroxide → HCID 13453791, compound

HRID 1906833Notes

Reaction equation

HRID 1906833 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][CH2:6][CH2:7][S:8][C:9]1[N:10]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:13]=1)C.[OH-].[Na+]>C(O)C>[C:26]1([N:10]2[C:11]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[C:12]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:13]=[C:9]2[S:8][CH2:7][CH2:6][CH2:5][C:4]([OH:32])=[O:3])[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13453788HCID 13453788, compound

Product 1

HCID 13453791HCID 13453791, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
80 °C

Procedure

80 g of 4-(1.4.5-triphenylimidazol-2-yl mercapto)-butyric acid ethyl ester are dissolved in 700 cc. of ethanol at 80° C. 22 g of sodium hydroxide dissolved in 200 cc. of ethanol are added thereto and the mixture is stirred for 3 hours at 80° C. The solvent is distilled off, the residue is washed with ether and acidified with dilute hydrochloric acid. The resulting acid is triturated in chloroform, the chloroform solution is washed with water, dried over sodium sulfate and the solvent is distilled off.

Workup

  1. customat 80° C
  2. distillationThe solvent is distilled off
  3. washthe residue is washed with ether
  4. customThe resulting acid is triturated in chloroform
  5. washthe chloroform solution is washed with water
  6. dry with materialdried over sodium sulfate
  7. distillationthe solvent is distilled off

Sources & evidence

ORD record
ord-342b4f2558ad4b40a06016c08286a96f
Source dataset
uspto-grants-1987_03
Patent number
US04654358

Reaction notes

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