HCID 54476646, compound → HCID 11189070, compound

Participants

Reaction Steps

A reaction mixture comprising 2.86 g of N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-methylcyclobutanecarboxamide, 1.88 g of 3-amino-4-benzoylpyrazole and 100 ml of glacial acetic acid was refluxed for 8 hours and then the solvent was removed in vacuo. The residue was partitioned between saturated aqueous sodium bicarbonate and dichloromethane. The organic layer was dried over anhydrous sodium sulfate and then passed through a short pad of hydrous magnesium silicate. The addition of hexane to the refluxing eluate induced crystallization. After cooling, the desired product was collected, giving 3.05 g, mp 168°-170° C.

Provenance & Evidence