HuagongsheHuagongshe Chemistry Print Report · For research reference only
[3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]methylcarbamic acid, methyl ester → [3-[3-(2-Furanylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]methylcarbamic acid, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]methylcarbamic acid, methyl ester | HCID 86741391 | — |
| Reactant | HCID 178509268 | HCID 178509268 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | [3-[3-(2-Furanylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]methylcarbamic acid, methyl ester | HCID 86741390 | 77.1% |
Reaction Steps
A reaction mixture comprising 2.62 g of [3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]methylcarbamic acid, methyl ester, 1.77 g of 3-amino-4-furoylpyrazole and 100 ml of glacial acetic acid was reacted as described in Example 29, giving 2.90 g of the desired product, mp 152°-154° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04654347 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-5dea22ac3e784594b4bada15033ec1a4 |
| Source note | uspto-grants-1987_03 |