Methanol → HCID 20211027, compound

Participants

Reaction Steps

To a stirred solution of 40 parts of 3,4-dihydro-2-(hydroxymethyl)-2H-1-benzopyran-6-carboxylic acid in 400 parts of methanol were added a few drops of sulfuric acid. Stirring was continued overnight at reflux. The reaction mixture was evaporated. The residue was taken up in 1,1'-oxybisethane. The whole was washed with a sodium hydroxide solution 10% and with water, dried, filtered and evaporated, yielding 24 parts (53.9%) of methyl 3,4-dihydro-2-(hydroxymethyl)-2H-1-benzopyran-6-carboxylate as a residue (intermediate 4).

Provenance & Evidence