Ethanol → HCID 20211023, compound

Participants

Reaction Steps

A mixture of 20 parts of 3,4,7,8,9,10-hexahydro-2H-naphtho[1,2-b]pyran-2-carboxylic acid, 200 parts of ethanol and 4.6 parts of sulfuric acid was stirred and refluxed for 2 hours. The reaction mixture was evaporated. Water and a sodium hydroxide solution were added to the residue. The product was extracted with dichloromethane. The extract was washed with water, dried, filtered and evaporated, yielding 21 parts (100%) of ethyl 3,4,7,8,9,10-hexahydro-2H-naphtho[1,2-b]pyran-2-carboxylate as a residue (intermediate 30).

Provenance & Evidence