HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(2-aminoethyl)benzoate → N-(2-[4-Carbomethoxyphenyl]-1-methylethyl)-2-(4-benzyloxy-3-nitrophenyl)-2-hydroxyethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(2-aminoethyl)benzoate | HCID 11183521 | — |
| Reactant | Methyl 4-(2-aminopropyl)benzoate | HCID 15034329 | — |
| Reactant | 4-Benzyloxy-3-nitrophenyl glyoxal | HCID 20134172 | — |
| Product | N-(2-[4-Carbomethoxyphenyl]-1-methylethyl)-2-(4-benzyloxy-3-nitrophenyl)-2-hydroxyethanamine | HCID 20134229 | — |
Reaction Steps
The title compound was prepared as a mixture of diastereoisomers by the process of Example 25, replacing phenyl glyoxal by 4-benzyloxy-3-nitrophenyl glyoxal and 2-(4-carbomethoxyphenyl)ethanamine by 2-(4-carbomethoxyphenyl)-1-methylethanamine. τ(CDCl3) 8.93 (3H, d, J=6 Hz), 6.70-7.80 (7H, m), 6.14 (3H, s), 5.40 (1H, m), 4.81 (2H, s) 2.30-3.10 (10H, m), 2.02 (2H, d, J=8 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04654371 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-b3fe069da47d4f1abf26ea07331b351c |
| Source note | uspto-grants-1987_03 |