HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Serine → Benzyl 2-amino-3-hydroxypropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Serine | HCID 5951 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Benzyl 2-amino-3-hydroxypropanoate | HCID 3788223 | — |
Reaction Steps
In a similar manner 1.09 grams (0.0105 mole) of serine, 1.76 grams (0.02 mole) of lithium bromide, 2.02 grams (0.0118 mole) of benzyl bromide and 16 grams of N-methylpyrrolidinone were stirred together at 25° C. for 16 hours and at 50° C. for 3 hours to obtain the desired benzyl α-amino-β-hydroxypropionate product. High pressure liquid chromatographic assay indicated a 86 percent yield of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04654433 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-dd50a23a8f9a43b38ce5a532536d3949 |
| Source note | uspto-grants-1987_03 |