Boron trifluoride etherate → N-Cbz-2-amino-2-methyl-1-[di-(t-butyl)methoxy]propane

HRID 1907001Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1907001
[C:1]([N:11]1[CH2:13][C:12]1([CH3:15])[CH3:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[C:16]([CH:20]([C:22]([CH3:25])([CH3:24])[CH3:23])[OH:21])([CH3:19])([CH3:18])[CH3:17].B(F)(F)F.CCOCC.C([O-])(O)=O.[Na+]>C(Cl)Cl>[C:1]([NH:11][C:12]([CH3:14])([CH3:15])[CH2:13][O:21][CH:20]([C:22]([CH3:25])([CH3:24])[CH3:23])[C:16]([CH3:19])([CH3:18])[CH3:17])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

Komponenten

6

Edukt 4

HCID 8000Boron trifluoride etherateHCID 1397902,2,4,4-Tetramethylpentan-3-olHCID 516892Sodium BicarbonateHCID 13930700HCID 13930700, Verbindung

Produkt 1

HCID 20201229N-Cbz-2-amino-2-methyl-1-[di-(t-butyl)methoxy]propane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

N-Cbz-2,2-Dimethyl aziridine and di-t-butylmethanol are dissolved in CH2Cl2 at 0° C. under argon. Boron trifluoride etherate is added and the flask is stirred overnight. The contents are poured into saturated NaHCO3 and extracted with ethyl acetate. The organic layer is dried over MgSO4 and evaporated to yield N-Cbz-2-amino-2-methyl-1-[di-(t-butyl)methoxy]propane.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer is dried over MgSO4
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-695621f1a4874acf8e1b80ef83f256a1
Quelldatensatz
uspto-grants-1987_03
Patentnummer
US04654439

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