Metformin Hydrochloride → HCID 178484382, compound

Temperature

50 °C

The Metformin Resin Complex was prepared by first dissolving 225 g of metformin HCl in 4 L of purified water, and then slowly adding 735 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. KOLLICOAT™ SR-30D (250 g) was first mixed with 150 g of purified water and the mixture was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried in a 50° C. VWR™ convection oven to the moisture content about 20%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and drying continued at 50° C. until the moisture content was between 3-7%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

1. additionslowly adding 735 g of AMBERLITE™
2. additionThe dispersion was mixed for 4 hours and upon completion
3. custombefore decanting the supernatant
4. customThe wet resin complex was then dried in a VWR™ convection oven
5. additionKOLLICOAT™ SR-30D (250 g) was first mixed with 150 g of purified water
6. additionthe mixture was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
7. customto form a uniform mass
8. customThe wet mass was again dried in a 50° C
9. customThe semi-dried granules were then milled through a 40 mesh screen
10. customdrying
11. customcontinued at 50° C. until the moisture content
12. customThe dried granules were then milled through a 40 mesh screen

ORD record

ord-d99d465fa64e4e1f97ad9e02531fabf1

Source dataset

uspto-grants-2013_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08597684B2