5-Bromo-2-chloro-3-nitropyridine → 5-Bromo-2-methoxy-3-nitropyridine

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Reaction Steps

A solution of 20.0 g (84.2 mmol) 5-bromo-2-chloro-3-nitro-pyridine in 50 mL MeOH is cooled to 0° C. and 15.8 mL (84.2 mmol) of a NaOMe solution in MeOH (30%) is added drop wise. The mixture is stirred at RT over night and then stirred under reflux for 24 h. The precipitate is filtered off, suspended in water and the suspension is stirred for 1 h. The product is filtered off and dried und vacuum at 60° C. Yield: 18.7 g (95%).

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