Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenylhydrazine | HCID 7516 | — |
| Reactant | Ethyl 4-chloro-6-nitroquinoline-3-carboxylate | HCID 13430300 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 178515216 | HCID 178515216 | 85% |
Reaction Steps
In a vial were added 4a, phenyl hydrazine and triethylamine. The vial was sealed and heated to 135° C. for 12 hours. The product was collected by filtration and was washed with methanol in 85% yield. 1H-NMR (DMSO-d6) δ (ppm): 7.19 (1H, tt, J=7.32, 1.22 Hz), 7.42 (2H, t, J=7.56 Hz), 7.84 (1H, d, J=9.03 Hz), 8.16 (2H, dd, J=8.30, 1.22 Hz), 8.82 (1H, s), 8.89 (1H, d, J=2.44 Hz). m/z 307.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08598159B2 |
|---|
| Source dataset | uspto-grants-2013_12 |
|---|
| ORD ID | ord-588e216a14a441a8af153ad8341bc7cb |
|---|
| Source note | uspto-grants-2013_12 |
|---|
