HCID 178492054, compound → HCID 178492053, compound

HRID 1907237Notes

Reaction equation

HRID 1907237 reaction equation
NC1C=CC2C3C(C(=O)N(C4C=CC=CC=4)N=3)=CNC=2C=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[C:45](=[O:46])[C:33]3=[CH:34][NH:35][C:36]4[CH:37]=[C:38]([N+:42]([O-])=O)[CH:39]=[CH:40][C:41]=4[C:32]3=[N:31]2)=[CH:26][CH:25]=1>>[NH2:42][C:38]1[CH:39]=[CH:40][C:41]2[C:32]3[C:33]([C:45](=[O:46])[N:30]([C:27]4[CH:28]=[CH:29][C:24]([O:23][CH3:22])=[CH:25][CH:26]=4)[N:31]=3)=[CH:34][NH:35][C:36]=2[CH:37]=1

Participants

3

Reactant 2

HCID 178492054HCID 178492054, compoundHCID 178507229HCID 178507229, compound

Product 1

HCID 178492053HCID 178492053, compound

Procedure

The title compound was prepared following the procedure described for 13a using 12c. 1H-NMR (DMSO-d6) δ (ppm): 6.74 (1H, d, J=2.20 Hz) 6.79 (1H, dd, J=8.79, 2.19 Hz), 7.42 (1H, d, J=8.79 Hz), 7.43 (1H, q, J=5.22 Hz), 7.86 (1H, d, J=8.51 Hz), 8.20 (1H, d, J=9.06 Hz), 8.21 (1H, q, J=5.21 Hz), 8.47 (1H, d, J=6.32 Hz). m/z 307.3 (MH+).

Sources & evidence

ORD record
ord-09c2060c3ffc413b979ef846b022e5d3
Source dataset
uspto-grants-2013_12
Patent number
US08598159B2

Reaction notes

Loading…