3,5-Dimethylpiperidine → HCID 178425481, compound

HRID 1907244Notes

Reaction equation

HRID 1907244 reaction equation
FC1C(N2CCNCC2)=C[C:9]2[NH:8][CH:7]=[C:6]3[C:18](=O)N(C4C=CC=CC=4)N=[C:5]3[C:4]=2[CH:3]=1.F[C:29]1[C:30]([F:49])=[CH:31][C:32]2[C:33]3[C:34]([C:39](=[O:48])[N:40]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[N:41]=3)=[CH:35][NH:36][C:37]=2[CH:38]=1.CC1CC(C)CNC1>>[CH3:18][CH:6]1[CH2:5][CH:4]([CH3:3])[CH2:9][N:8]([C:29]2[C:30]([F:49])=[CH:31][C:32]3[C:33]4[C:34]([C:39](=[O:48])[N:40]([C:42]5[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=5)[N:41]=4)=[CH:35][NH:36][C:37]=3[CH:38]=2)[CH2:7]1

Participants

4

Reactant 3

HCID 1182593,5-DimethylpiperidineHCID 178515218HCID 178515218, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178425481HCID 178425481, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27a and 3,5-dimethylpiperidine. 1H-NMR (DMSO-d6) δ (ppm): 0.99 (6H, d, J=6.33 Hz), 1.80 (4H, br), 2.47 (2H, t, J=8.62 Hz), 3.46 (2H, brd, J=11.81 Hz), 7.13 (1H, m), 7.26 (1H, d, J=7.97 Hz), 7.40 (2H, t, J=7.69 Hz), 7.79 (1H, d, J=13.18 Hz), 8.19 (2H, d, J=7.69 Hz), 8.65 (1H, s). m/z 391.5 (MH+).

Sources & evidence

ORD record
ord-214273be8ef44c8ba6fe139e617ccd19
Source dataset
uspto-grants-2013_12
Patent number
US08598159B2

Reaction notes

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