Hexahydro-1,4-diazepine → HCID 178515222, compound

HRID 1907248Notes

Reaction equation

HRID 1907248 reaction equation
[F:1][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[N:20]=[C:5]3[C:4]=2[CH:3]=1.F[C:29]1C(F)=CC2C3C(C(=O)N(C4C=CC=CC=4)N=3)=CNC=2C=1.N1CCCNCC1>>[F:1][C:2]1[C:11]([N:12]2[CH2:13][CH2:14][CH2:29][NH:15][CH2:16][CH2:17]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[N:20]=[C:5]3[C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 68163Hexahydro-1,4-diazepineHCID 178515218HCID 178515218, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178515222HCID 178515222, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27a and homopiperazine. 1H-NMR (DMSO-d6) δ (ppm): 1.98 (2H, brm), 2.48 (2H, brm), 2.67 (2H, brm), 3.45 (4H, brm), 7.15 (2H, m), 7.40 (2H, m), 7.76 (1H, d, J=2.91 Hz), 8.20 (2H, m), 8.64 (1H, s). m/z 378.2 (MH+).

Sources & evidence

ORD record
ord-d7715753308a477db8dc8f86607a5934
Source dataset
uspto-grants-2013_12
Patent number
US08598159B2

Reaction notes

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