反应详情

A solution of 3-(3-bromophenylamino)-1-(2-chlorophenyl)propan-1-one (50 mg, 0.148 mmol) in 4:1 THF/methanol (5 mL) was cooled to 0° C. NaBH4 (11 mg, 2 equiv) was added. After 10 min, the mixture was warmed up to rt slowly and stirred for 2 h. The mixture was concentrated, diluted with EtOAc (7 mL), washed with 1% aq HCl (1 mL), and dried over Na2SO4. Filtration and concentration afforded crude 3-(3-bromophenylamino)-1-(2-chlorophenyl)propan-1-ol which was used without further purification. LC-MS (3 min) tR=1.93 min, m/z=342,343(M+1).

1. concentrationThe mixture was concentrated
2. additiondiluted with EtOAc (7 mL)
3. washwashed with 1% aq HCl (1 mL)
4. dry with materialdried over Na2SO4
5. filtrationFiltration and concentration