HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-sulfonyl chloride → (R)-4a-Ethoxymethyl-1-(4-fluorophenyl)-6-[[2H-pyrido[3.2-b]-1,4-oxazin-7-yl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-sulfonyl chloride | HCID 24229646 | — |
| Reactant | (R)-4a-Ethoxymethyl-1-(4-fluorophenyl)-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester | HCID 66780480 | — |
| Product | (R)-4a-Ethoxymethyl-1-(4-fluorophenyl)-6-[[2H-pyrido[3.2-b]-1,4-oxazin-7-yl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene | HCID 86669984 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 1c using (R)-4a-ethoxymethyl-1-(4-fluorophenyl)-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester and 4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-sulfonyl chloride. LCMS (Method C): 540 (M+H)+, Retention time 11.9 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598154B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-56e57f63d6134578a7edc343be91ae3a |
| Source note | uspto-grants-2013_12 |