2-Chloro-5-pyridinesulfonyl chloride → HCID 86669986, compound

HRID 1907282Notes

Reaction equation

C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C@:10]([CH2:28][O:29][CH3:30])([CH2:11][C:12]3[CH:20]=[N:19][N:18]([C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=4)[C:13]=3[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[Cl:31][C:32]1[N:37]=[CH:36][C:35]([S:38](Cl)(=[O:40])=[O:39])=[CH:34][CH:33]=1>>[Cl:31][C:32]1[N:37]=[CH:36][C:35]([S:38]([N:8]2[CH2:17][CH2:16][C:15]3[C@:10]([CH2:28][O:29][CH3:30])([CH2:11][C:12]4[CH:20]=[N:19][N:18]([C:21]5[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=5)[C:13]=4[CH:14]=3)[CH2:9]2)(=[O:40])=[O:39])=[CH:34][CH:33]=1

Participants

Reactant 2

HCID 27927922-Chloro-5-pyridinesulfonyl chloride

HCID 66779665(R)-1-(4-Fluorophenyl)-4a-methoxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester

Product 1

HCID 86669986HCID 86669986, compound

Procedure

The title compound was prepared by the method of Preparation 2b using (R)-1-(4-fluorophenyl)-4a-methoxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester and 6-chloropyridine-3-sulfonyl chloride. LCMS (Method B): 489 (M+H)+, Retention time 3.9 minutes.

Sources & evidence

ORD record: ord-f47223fcb1cd4e1f8550c61673edf066
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598154B2

Reaction notes

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