HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → (R)-4a-Ethoxymethyl-1-(4-fluorophenyl)-6-[[6-methylamino-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | HCID 86669985 | HCID 86669985 | — |
| Product | (R)-4a-Ethoxymethyl-1-(4-fluorophenyl)-6-[[6-methylamino-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene | HCID 56848921 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 4b using (R)-6-(6-chloropyridine-3-sulfonyl)-4a-ethoxymethyl-1-(4-fluorophenyl)-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene and methylamine. LCMS (Method B): 498 (M+H)+, Retention time 3.6 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598154B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-274f3811180e4888a3e238e774f5d06e |
| Source note | uspto-grants-2013_12 |