Dimethylamine → (R)-6-[[6-Dimethylamino-3-pyridinyl]sulfonyl]-1-(4-fluorophenyl)-4a-methoxymethyl-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

HRID 1907288Notes

Reaction equation

HRID 1907288 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:20][CH2:19][C:18]3[C@:13]([CH2:31][O:32][CH3:33])([CH2:14][C:15]4[CH:23]=[N:22][N:21]([C:24]5[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=5)[C:16]=4[CH:17]=3)[CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:34][NH:35][CH3:36]>>[CH3:34][N:35]([CH3:36])[C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:20][CH2:19][C:18]3[C@:13]([CH2:31][O:32][CH3:33])([CH2:14][C:15]4[CH:23]=[N:22][N:21]([C:24]5[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=5)[C:16]=4[CH:17]=3)[CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 86669986HCID 86669986, compound

Product 1

HCID 56848923(R)-6-[[6-Dimethylamino-3-pyridinyl]sulfonyl]-1-(4-fluorophenyl)-4a-methoxymethyl-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

Procedure

The title compound was prepared by the method of Preparation 4b using (R)-6-(6-chloropyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-methoxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene and dimethylamine. LCMS (Method C): 498 (M+H)+, Retention time 11.4 minutes.

Sources & evidence

ORD record
ord-7e9c2d429bca42469e56e2f5f01ec21c
Source dataset
uspto-grants-2013_12
Patent number
US08598154B2

Reaction notes

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