HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromopyridine-3-sulfonyl chloride → (R)-6-(5-Bromopyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-methoxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromopyridine-3-sulfonyl chloride | HCID 20324474 | — |
| Reactant | (R)-1-(4-Fluorophenyl)-4a-methoxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester | HCID 66779665 | — |
| Product | (R)-6-(5-Bromopyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-methoxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene | HCID 66779670 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 1c using (R)-1-(4-Fluorophenyl)-4a-methoxymethyl-1,4,4a,5,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthalene-6-carboxylic acid tert-butyl ester and 5-bromopyridine-3-sulfonyl chloride. LCMS (Method D): 533 (M+H)+, Retention time 4.1 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598154B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-5083ddeb1a624cbf8a8073c0a41ab44a |
| Source note | uspto-grants-2013_12 |