HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Chloromethyl)-1,3-oxazole → (R)-6-(6-Azetidin-1-yl-pyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-(oxazol-2-ylmethoxymethyl)-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Chloromethyl)-1,3-oxazole | HCID 21957543 | — |
| Reactant | [(R)-6-(6-azetidin-1-yl-pyridine-3-sulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthal-en-4a-yl]methanol | HCID 68194435 | — |
| Product | (R)-6-(6-Azetidin-1-yl-pyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-(oxazol-2-ylmethoxymethyl)-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene | HCID 66780470 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 2b using [(R)-6-(6-azetidin-1-yl-pyridine-3-sulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1,2,6-triazacyclopenta[b]naphthal-en-4a-yl]methanol and 2-chloromethyloxazole. LCMS (Method C): 577 (M+H)+, Retention time 10.2 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598154B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-d02c1ac507094d9baded4c66ee744af5 |
| Source note | uspto-grants-2013_12 |