HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → (R)-1-(4-Fluorophenyl)-4a-methoxymethyl-6-[(1S,4S)-6-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)pyridine-3-sulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (1S,4S)-2-oxa-5-azabicyclo(2.2.1)heptane hydrochloride | HCID 21303398 | — |
| Reactant | HCID 86669986 | HCID 86669986 | — |
| Product | (R)-1-(4-Fluorophenyl)-4a-methoxymethyl-6-[(1S,4S)-6-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)pyridine-3-sulfonyl]-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene | HCID 68069687 | — |
Reaction Steps
The title compound was prepared by the method of Example 20 using (R)-6-(6-chloropyridine-3-sulfonyl)-4a-methoxymethyl-1-(4-fluorophenyl)-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene, diisopropylethylamine and (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride. LCMS (Method F): 552 (M+H)+, Retention time 4.7 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598154B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-71f4c7d00ad84609aa0037f7fc379ca8 |
| Source note | uspto-grants-2013_12 |