Bromomethylcyclopropane → (R)-4a-Cyclopropylmethoxymethyl-1-(4-fluorophenyl)-6-(6-morpholin-4-yl-pyridine-3-sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene

Participants

Reaction Steps

The title compound was prepared by the method of Preparation 25b using [(R)-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalen-4a-yl]methanol and cyclopropylmethyl bromide. 1H NMR (400 MHz, CHCl3-d): δ 8.54 (d, 1H), 7.80 (dd, 1H), 7.51-7.39 (m, 3H), 7.14 (t, 2H), 6.62 (d, 1H), 4.17 (dd, 1H), 3.80 (t, 4H), 3.65 (t, 4H), 3.45 (d, 1H), 3.30 (dd, 2H), 3.27-3.14 (m, 2H), 2.75-2.65 (m, 1H), 2.43-2.33 (m, 2H), 2.21-2.10 (m, 1H), 2.10 (d, 1H), 1.12-1.01 (m, 1H), 0.49 (dd, 2H), 0.26-0.15 (m, 2H).

Provenance & Evidence