3-Fluoropyrrolidine → HCID 56849162, compound

Participants

Reaction Steps

The title compound was prepared by the method of Example 20 using (R)-6-(6-chloropyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-(2-methoxyethoxymethyl)-4,4a,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene and (R)-3-fluoropyrrolidine. 1H NMR (400 MHz, CHCl3-d): δ 8.55-8.44 (m, 1H), 7.50-7.39 (m, 3H), 7.19-7.11 (m, 2H), 6.41 (d, 1H), 6.27 (d, 1H), 5.46 (s, 1H), 5.33 (s, 1H), 4.15 (dd, 1H), 3.87 (dd, 2H), 3.73 (d, 1H), 3.68-3.55 (m, 7H), 3.38 (s, 3H), 3.25 (d, 1H), 3.14 (d, 1H), 2.80-2.69 (m, 1H), 2.39-2.25 (m, 3H), 2.17-2.03 (m, 3H).

Provenance & Evidence