3-Fluoropyrrolidine → 2-{(R)-1-(4-Fluorophenyl)-6-[6-((R)-3-fluoropyrrolidin-1-yl)-pyridine-3-sulphonyl]-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-ylmethoxy}-ethanol

Participants

Reaction Steps

The title compound was prepared by the method of Example 20 using 2-[(R)-6-(6-chloropyridine-3-sulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-ylmethoxy]-ethanol and (R)-3-fluoropyrrolidine. 1H NMR (400 MHz, CHCl3-d): δ 8.55 (d, 1H), 7.78 (dd, 1H), 7.51-7.40 (m, 3H), 7.15 (t, 2H), 6.41 (d, 1H), 6.28 (s, 1H), 5.40 (d, 1H), 4.26 (d, 1H), 3.91 (s, 2H), 3.74-3.61 (m, 6H), 3.55 (d, 1H), 3.48 (d, 1H), 3.21 (d, 1H), 3.13 (d, 1H), 2.49-2.38 (m, 2H), 2.21 (d, 1H), 2.07 (d, 1H).

Provenance & Evidence