3-Fluoropyrrolidine → HCID 56849220, compound

Participants

Reaction Steps

The title compound was prepared by the method of Example 20 using (R)-6-(6-chloropyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-(5-methyl-isoxazol-3-ylmethoxymethyl)-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene and (R)-3-fluoropyrrolidine. 1H NMR (400 MHz, CHCl3-d): δ 8.55 (d, 1H), 7.77 (dd, 1H), 7.49-7.37 (m, 3H), 7.14 (t, 2H), 6.41 (d, 1H), 6.35-6.20 (m, 2H), 5.40 (d, 1H), 4.62-4.48 (m, 2H), 4.19 (dd, 1H), 3.78-3.70 (m, 3H), 3.51 (d, 1H), 3.18-3.10 (m, 2H), 2.69-2.60 (m, 1H), 2.42 (d, 3H), 2.21 (d, 1H), 2.10 (d, 1H).

Provenance & Evidence