HuagongsheHuagongshe Chemistry Print Report · For research reference only
(s)-3-Fluoropyrrolidine hydrochloride → (R)-1-(4-Fluorophenyl)-6-[5-((S)-3-fluoropyrrolidin-1-yl)-pyridine-3-sulfonyl]-4a-methoxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (s)-3-Fluoropyrrolidine hydrochloride | HCID 16217739 | — |
| Reactant | (R)-6-(5-Bromopyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-methoxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene | HCID 66779670 | — |
| Product | (R)-1-(4-Fluorophenyl)-6-[5-((S)-3-fluoropyrrolidin-1-yl)-pyridine-3-sulfonyl]-4a-methoxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene | HCID 56849285 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 12c using (R)-6-(5-bromopyridine-3-sulfonyl)-1-(4-fluorophenyl)-4a-methoxymethyl-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triazacyclopenta[b]naphthalene and (S)-3-fluoropyrrolidine hydrochloride. LCMS (Method F): 542 (M+H)+, Retention time 4.9 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598154B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-d224d1b1bde14a9f9911372a3b907f26 |
| Source note | uspto-grants-2013_12 |