反应详情

A solution of (R)-1-(4-fluorophenyl)-6-(6-morpholin-4-yl-pyridine-3-sulfonyl]-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester (0.3 g) in tetrahydrofuran (10 mL) and water (10 mL) was treated with lithium hydroxide monohydrate (0.11 g) at 60° C. for 16 hours. The cooled mixture was diluted with ethyl acetate and 1.0 M aqueous hydrochloric acid solution. The aqueous phase was washed with ethyl acetate, the combined organic phases were washed with brine and dried over sodium sulfate. The solvent was removed under reduced pressure to afford the title compound as a foam (0.3 g). LCMS (Method G): 540.4 (M+H)+, Retention time 3.16 minutes.

1. washThe aqueous phase was washed with ethyl acetate
2. washthe combined organic phases were washed with brine
3. dry with materialdried over sodium sulfate
4. customThe solvent was removed under reduced pressure