HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Chloromethyl)-5-methyl-1,2-oxazole → (R)-1-(4-Fluorophenyl)-6-(6-morpholin-4-yl-pyridine-3-sulfonyl]-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid 5-methylisoxazol-3-ylmethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Chloromethyl)-5-methyl-1,2-oxazole | HCID 2735763 | — |
| Reactant | (R)-1-(4-Fluorophenyl)-6-(6-morpholin-4-yl-pyridine-3-sulfonyl]-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid | HCID 66780217 | — |
| Product | (R)-1-(4-Fluorophenyl)-6-(6-morpholin-4-yl-pyridine-3-sulfonyl]-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid 5-methylisoxazol-3-ylmethyl ester | HCID 56849415 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 54b using (R)-1-(4-fluorophenyl)-6-(6-morpholin-4-yl-pyridine-3-sulfonyl]-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid and 3-chloromethyl-5-methyl isoxazole. LCMS (Method F): 635 (M+H)+, Retention time 4.90 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598154B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-bfe9dd73401d4368b25b47bd634e35e4 |
| Source note | uspto-grants-2013_12 |