(3R)-3-fluoropyrrolidine hydrochloride → HCID 66779871, compound

HRID 1907325Notes

Reaction equation

HRID 1907325 reaction equation
[CH3:1][O:2][C:3]([C@@:5]12[CH2:14][N:13]([S:15]([C:18]3[CH:19]=[N:20][C:21](Cl)=[CH:22][CH:23]=3)(=[O:17])=[O:16])[CH2:12][CH2:11][C:10]1=[CH:9][C:8]1[N:25]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)[N:26]=[CH:27][C:7]=1[CH2:6]2)=[O:4].Cl.[F:36][C@@H:37]1[CH2:41][CH2:40][NH:39][CH2:38]1>>[CH3:1][O:2][C:3]([C@@:5]12[CH2:14][N:13]([S:15]([C:18]3[CH:19]=[N:20][C:21]([N:39]4[CH2:40][CH2:41][C@@H:37]([F:36])[CH2:38]4)=[CH:22][CH:23]=3)(=[O:17])=[O:16])[CH2:12][CH2:11][C:10]1=[CH:9][C:8]1[N:25]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)[N:26]=[CH:27][C:7]=1[CH2:6]2)=[O:4]

Participants

3

Reactant 2

HCID 2759162(3R)-3-fluoropyrrolidine hydrochlorideHCID 86669987HCID 86669987, compound

Product 1

HCID 66779871HCID 66779871, compound

Procedure

The title compound was prepared by the method of Example 20 using (R)-6-(6-chloropyridine-3-sulfonyl)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1,2,6-triaza-cyclopenta[b]naphthalene-4a-carboxylic acid methyl ester and (R)-3-fluoropyrrolidine hydrochloride. LCMS (Method G): 556.2 (M+H)+, Retention time 3.4 minutes.

Sources & evidence

ORD record
ord-6fe28f481734449dbb3361f5d74ab96a
Source dataset
uspto-grants-2013_12
Patent number
US08598154B2

Reaction notes

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