HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-bromopyridine → 6-bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-bromopyridine | HCID 70622 | — |
| Reactant | 1,1-Dimethoxyethyl(dimethyl)amine | HCID 87835 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine | HCID 611191 | — |
| Product | HCID 66746222 | HCID 66746222 | — |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
To a stirred solution of 2-amino-5-bromopyridine (1.73 g, 10 mmol) in N,N-dimethylformamide (20 mL) was added dimethylacetamide dimethylacetal (3.99 g, 30 mmol). The reaction mixture was heated to 130° C. overnight. After cooling to room temperature, the volatiles were removed under reduced pressure to afford the desired product N′-(5-bromo-pyridin-2-yl)-N,N-dimethyl-acetamidine as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598163B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-b817a87e2c7b4092b7cd2961a03eab0e |
| Source note | uspto-grants-2013_12 |