7-Bromo[1,2,4]triazolo[1,5-a]pyridine → HCID 66745486, compound

Participants

Reaction Steps

The title compound was prepared from (S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-3-{(S)-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-[1,3]oxazinan-2-one and 7-bromo-[1,2,4]triazolo[1,5-a]pyridine following a procedure analogous to that described in EXAMPLE 7. Yield: 68% of theory; Mass spectrum (ESI+): m/z=471 [M+H]+; 1H NMR (400 MHz, DMSO-d6) δ 0.82 (s, 3H), 1.19 (s, 3H), 1.49 (d, J=7.1 Hz, 3H), 2.03 (s, 2H), 2.14-2.23 (m, 1H), 2.39-ca. 2.55 (m, 2H) superimposed on DMSO-d5, 3.01-3.09 (m, 1H), 4.23 (s, 1H), 5.46 (q, J=7.1 Hz, 1H), 7.02 (dm, J=8.3 Hz, 2H), 7.27-7.41 (m, 5H), 7.46 (dm, J=7.2, 1.8 Hz, 1H), 7.62 (dm, J=8.3 Hz, 2H), 8.06 (hardly resolved d, 1H), 8.52 (s, 1H), 8.98 (d, J=7.2 Hz, 1H).

Provenance & Evidence