Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Chlorophenacyl bromide | HCID 68303 | — |
| Reactant | 2-Pyridinamine, 5-iodo- | HCID 88579 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | HCID 1511765 | HCID 1511765 | 68.5% |
Reaction Steps
5.0 g of 2-amino-5-iodopyridine, 5.3 g of 2-bromo-1-(4-chlorophenyl)ethanone and 2.67 g of sodium hydrogen carbonate in 150 ml of n-propanol are placed in a round-bottomed flask. The mixture is heated at 80° C. for 40 h and left to cool, and 700 ml of water are added. The precipitate is recovered by filtration, washed with water and dried under reduced pressure. 5.51 g of compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08598166B2 |
|---|
| Source dataset | uspto-grants-2013_12 |
|---|
| ORD ID | ord-e4aca0ad480e4459b3da1ea671a2aee8 |
|---|
| Source note | uspto-grants-2013_12 |
|---|
