Sodium borohydride → HCID 44233541, compound

HRID 1907348Notes

Reaction equation

HRID 1907348 reaction equation
[BH4-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][C:15]([C:18]4[O:22][C:21]([CH:23]=[O:24])=[CH:20][CH:19]=4)=[CH:14][N:13]3[CH:25]=2)=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][C:15]([C:18]4[O:22][C:21]([CH2:23][OH:24])=[CH:20][CH:19]=4)=[CH:14][N:13]3[CH:25]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86651941HCID 86651941, compound

Product 1

HCID 44233541HCID 44233541, compoundYield 37.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

122 mg of sodium borohydride are added, in small portions, to 104 mg of 5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours, and the solvent is then evaporated off under reduced pressure. The residue is taken up between dichloromethane and water. The organic phase is separated, dried over sodium sulphate and concentrated under reduced pressure. 39 mg of compound are obtained.

Workup

  1. customthe solvent is then evaporated off under reduced pressure
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-ab665422284d4db49f6842d7f9bea109
Source dataset
uspto-grants-2013_12
Patent number
US08598166B2

Reaction notes

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