HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis-(1H-imidazol-2-YL)-methanone → 7-methoxy-3,4-dihydro-1H-quinazolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Reactant | 2-Aminomethyl-5-methoxyaniline | HCID 53630728 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-methoxy-3,4-dihydro-1H-quinazolin-2-one | HCID 53630727 | 78.9% |
Reaction Steps
2-aminomethyl-5-methoxyaniline (1.2 g. 7.9 mmol) and carbonyl diimidazole (1.53 g, 9.5 mmol) were added to THF (100 ml) and the mixture was stirred at room temperature overnight. The insoluble matter precipitated was obtained by filtration, washed with dichloromethane and water, dried to obtain 7-methoxy-3,4-dihydro-1H-quinazolin-2-one (1.11 g) as white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598162B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-4bc7756397d142a09798286d1537a6cd |
| Source note | uspto-grants-2013_12 |