HCID 86762144, compound → HCID 86762143, compound

Participants

Reaction Steps

To a solution of (±)-tert-butyl (4aR,7aR)-7a-(2-fluoro-5-nitrophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate (31 mg, 0.078 mmol) in methanol (3.9 mL) was added 10% Pd/C (17 mg), and the reaction mixture was stirred at rt under a hydrogen atmosphere for 2 h. The reaction mixture was filtered through a pad of Celite and concentrated directly to give the title compound as a colorless oil (30 mg, 99%). 1H NMR (500 MHz, CDCl3) δ 6.87 (2H, m), 6.63 (1H, m), 4.17 (1H, m), 4.09 (1H, m), 3.35 (1H, m), 3.05 (1H, m), 2.89 (1H, m), 2.35 (1H, m), 2.23 (1H, m), and 1.51 (9H, m). MS (M+H)+: 368.2.

Provenance & Evidence