HCID 86762147, compound → HCID 86762148, compound

Participants

Reaction Steps

A suspension of tert-butyl ((4aR,7aR)-7a-(5-azido-2-fluorophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-yl)carbamate (50 mg, 0.127 mmol), 10% Pd/C (135 mg, 0.127 mmol) in methanol (5525 μL) was stirred under hydrogen balloon at rt for 12 h. The reaction mixture was filtered and the filtrate was evaporated in vacuo to tert-butyl ((4aS,7aS)-7a-(5-amino-2-fluorophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-yl)carbamate (44 mg, 0.120 mmol, 94% yield) as a yellowish oil. This material was used directly for the next reaction without purification. MS (M+H)+: 368.14.

Provenance & Evidence