Trifluoroacetic acid → HCID 86762166, compound

Participants

Reaction Steps

A solution of tert-butyl ((4aR,7aR)-7a-(2-fluoro-5-(3-fluoropicolinamido)phenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-yl)carbamate (6 mg, 0.012 mmol) and TFA (18.85 μL, 0.245 mmol) in DCM (122 μL) was stirred at rt for 3 h, and the solvents were removed to give N-(3-((4aR,7aR)-2-amino-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-3-fluoropicolinamide (7 mg) as its TFA salt as a colorless oil. 1H NMR (500 MHz, METHANOL-d4) δ 8.84-8.37 (br. s, 2H), 8.17 (dd, J=7.2, 2.3 Hz, 1H), 7.92-7.76 (m, 2H), 7.26 (dd, J=11.1, 8.9 Hz, 1H), 4.37-4.19 (m, 2H), 3.46 (dd, J=13.6, 3.8 Hz, 1H), 3.35-3.25 (m, 1H), 3.19-3.04 (m, 1H), 2.32 (q, J=7.0 Hz, 2H). MS (M+H)+: 391.10.

Provenance & Evidence